Het-PDB Navi2 (PDB: 5NWZ)

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Ligands
Code	Name		Style	Show	Link
9CT	~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide				PoSSuM

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Download interaction data: 5NWZ

Code :

5NWZ PDBj RCSB PDB PDBe

Header :

HORMONE/GROWTH FACTOR

Title :

FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA159527

Release Data :

2018-04-04

Compound :

mol_id	molecule	chains	synonym
1	Fibroblast growth factor receptor 4	A,B	FGFR-4
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Zou, C.

Keywords :

HORMONE-GROWTH FACTOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.37 Å )

Citation :

Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.

Fairhurst, R.A.,Knoepfel, T.,Leblanc, C. et al.
(2017) Medchemcomm 8 : 1604 - 1613

Chain :

A, B

UniProt :

P22455 (FGFR4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:11433297, PubMed:17311277, PubMed:18480409, PubMed:18670643
	-

PDB ID: 5NWZ