Brand  (β version)

PDB ID: 5NWH

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Ligands
Code Name Style Show Link
9CH 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-yl-purine-2,6-dione PoSSuM
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Structure summary

Code : 5NWH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Potent inhibitors of NUDT5 silence hormone signaling in breast cancer
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 ADP-sugar pyrophosphatase A,B 8-oxo-dGDP phosphatase,Nuclear ATP-synthesis protein NUDIX5,Nucleoside diphosphate-linked moiety X motif 5,hNUDT5,YSA1H
ec: 3.6.1.13,3.6.1.58,2.7.7.96
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NUDT5, NUDIX5, HSPC115
Authors : Carter, M., Stenmark, P.
Keywords : NUDIX, Inhibitor, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page, B.D.G.,Valerie, N.C.K.,Wright, R.H.G.  et al.
(2018)  Nat Commun  9 : 250 - 250

PubMed: 29343827
DOI: 10.1038/s41467-017-02293-7

Reaction

Chain : A, B
UniProt : Q9UKK9 (NUDT5_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate 2.7.7.96 PubMed:27257257
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ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+) 3.6.1.13 PubMed:17052728, PubMed:21389046
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate + H(+) 3.6.1.58 PubMed:17052728, PubMed:19699693, PubMed:21389046
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:17052728
ECO:0000269 | PubMed:18462755
ECO:0000269 | PubMed:21768126
Binds 3 Mg(2+) ions per subunit.