Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9AE (2~{S})-6-methyl-~{N}-propan-2-yl-heptan-2-amine
SO4 Sulfate ion
Code : 5NV2
Header : TRANSFERASE
Title : Human DNMT3B PWWP domain in complex with N-isopropyl-1,5-dimethylhexylamine (Metron S)
Release Data : 2018-05-30
Compound :
mol_id molecule chains synonym
1 DNA (cytosine-5)-methyltransferase 3B A,B Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB
ec: 2.1.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DNMT3B
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28-MHL
Authors : Rondelet, G., Wouters, J.
Keywords : DNMT3B PWWP DOMAIN, HISTONE BINDING, BETA BARREL, LIGAND, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.0290 Å )
Citation :

Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors

Rondelet, G.,Dal Maso, T.,Maniquet, A.  et al.
To Be Published 

Chain : A, B
UniProt : Q9UBC3 (DNM3B_HUMAN)
Reaction : S-adenosyl-L-methionine + DNA = S-adenosyl-L- homocysteine + DNA containing 5-methylcytosine.