Brand  (β version)

PDB ID: 5NSD

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Ligands
Code Name Style Show Link
96Q (~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide PoSSuM
GOL Glycerol PoSSuM
PO4 Phosphate ion PoSSuM
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Structure summary

Code : 5NSD   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Co-crystal structure of NAMPT dimer with KPT-9274
Release Data : 2018-02-14
Compound :
mol_id molecule chains synonym
1 Nicotinamide phosphoribosyltransferase A,B Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
ec: 2.4.2.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NAMPT, PBEF, PBEF1
Authors : Neggers, J.E., Kwanten, B., Dierckx, T., Noguchi, H., Voet, A., Vercruysse, T., Baloglu, E., Senapedis, W., Jacquemyn, M., Daelemans, D.
Keywords : drug target, NAMPT, CRISPR/Cas, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.046 Å )
Citation :

Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes.

Neggers, J.E.,Kwanten, B.,Dierckx, T.  et al.
(2018)  Nat Commun  9 : 502 - 502

PubMed: 29402884
DOI: 10.1038/s41467-017-02349-8

Reaction

Chain : A, B
UniProt : P43490 (NAMPT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + H(+) + nicotinamide 2.4.2.12 UniProtKB:Q99KQ4
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