Brand  (β version)

PDB ID: 5NRW

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Ligands
Code Name Style Show Link
96N 4-ethanoyl-3-ethyl-5-methyl-~{N}-(naphthalen-1-ylmethyl)-1~{H}-pyrrole-2-carboxamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5NRW   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4
Release Data : 2017-08-16
Compound :
mol_id molecule chains
1 CREB-binding protein A
ec: 2.3.1.48
fragment: bromodomain, UNP residues 1081-1197
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CREBBP, CBP
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Huegle, M., Wohlwend, D.
Keywords : bromodomain, protein-inhibitor complex, CBP, epigenetics, transcription
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

Hugle, M.,Lucas, X.,Ostrovskyi, D.  et al.
(2017)  Angew. Chem. Int. Ed. Engl.  56 : 12476 - 12480

PubMed: 28766825
DOI: 10.1002/anie.201705516

Reaction

Chain : A
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone] 2.3.1.48 PubMed:24616510
left-to-right
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826