Brand  (β version)

PDB ID: 5NRN

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Ligands
Code Name Style Show Link
95W 5-methyl-1-[1-[(6-phenoxypyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4-dione PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5NRN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Mtb TMK crystal structure in complex with compound 3
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 Thymidylate kinase A,B Thymidine monophosphate kinase,dTMP kinase,TMPK
ec: 2.7.4.9
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Escherichia coli  (taxid:562)
gene: tmk, Rv3247c
expression_system_variant: BLi5
Authors : Merceron, R., Song, L., Munier-Lehmann, H., Van Calenbergh, S., Savvides, S.
Keywords : Thymidylate kinase, Nucleotide Binding, inhibitor, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Mtb TMK crystal structure in complex with compound LS3080

Merceron, R.,Song, L.,Munier-Lehmann, H.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : P9WKE1 (KTHY_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
dTMP + ATP = dTDP + ADP 2.7.4.9 PubMed:11369858
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 1 Mg(2+) ion per subunit. This ion is required for catalysis, binding to the active site transiently (at the TMP-binding site), and probably acting as a clamp between the phosphoryl donor and acceptor.