Brand  (β version)

PDB ID: 5NRA

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Ligands
Code Name Style Show Link
95K 1-(5-azanyl-4~{H}-1,2,4-triazol-3-yl)-~{N}-[2-(4-bromophenyl)ethyl]-~{N}-(2-methylpropyl)piperidin-4-amine PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 5NRA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7g
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 Chitotriosidase-1 A Chitinase-1
ec: 3.2.1.14
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: CHIT1
expression_system_cell_line: HEK293T
Authors : Mazur, M., Olczak, J., Olejniczak, S., Koralewski, R., Czestkowski, W., Jedrzejczak, A., Golab, J., Dzwonek, K., Dymek, B., Sklepkiewicz, P., Zagozdzon, A., Noonan, T., Mahboubi, K., Conway, B., Sheeler, R., Beckett, P., Hungerford, W.M., Podjarny, A., Mitschler, A., Cousido-Siah, A., Fadel, F., Golebiowski, A.
Keywords : chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7g, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.267 Å )
Citation :

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.

Mazur, M.,Olczak, J.,Olejniczak, S.  et al.
(2018)  J. Med. Chem.  61 : 695 - 710

PubMed: 29283260
DOI: 10.1021/acs.jmedchem.7b01051

Reaction

Chain : A
UniProt : Q13231 (CHIT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. 3.2.1.14 PubMed:15664516, PubMed:19725875, PubMed:7836450
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