Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
94Z 3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]-4-oxidanylidene-butanoyl]amino]benzamide
Code : 5NQE
Header : TRANSFERASE
Title : Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor
Release Data : 2017-05-24
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase 14 A,B PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2
ec: 2.4.2.30
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PARP14, BAL2, KIAA1268
expression_system_variant: R3 pRARE
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Karlberg, T., Thorsell, A.G., Schuler, H.
Keywords : ADP-ribosylation, Inhibitor complex, Transferase domain, transferase
Exp. method : X-RAY DIFFRACTION ( 2.71 Å )
Citation :

Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.

Upton, K.,Meyers, M.,Thorsell, A.G.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 2907 - 2911

PubMed: 28495083
DOI: 10.1016/j.bmcl.2017.04.089

Chain : A, B
UniProt : Q460N5 (PAR14_HUMAN)
Reaction : NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.