Het-PDB Navi2 (PDB: 5NQE)

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Ligands
Code	Name		Style	Show	Link
94Z	3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]-4-oxidanylidene-butanoyl]amino]benzamide				PoSSuM

Non-standard Residues
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Download interaction data: 5NQE

Code :

5NQE PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor

Release Data :

2017-05-24

Compound :

mol_id	molecule	chains	synonym
1	Poly [ADP-ribose] polymerase 14	A,B	PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2
	ec: 2.4.2.30

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: PARP14, BAL2, KIAA1268 expression_system_variant: R3 pRARE expression_system_vector_type: plasmid expression_system_plasmid: pNIC28-Bsa4

Authors :

Karlberg, T., Thorsell, A.G., Schuler, H.

Keywords :

ADP-ribosylation, Inhibitor complex, Transferase domain, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.71 Å )

Citation :

Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.

Upton, K.,Meyers, M.,Thorsell, A.G. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 2907 - 2911

Chain :

A, B

UniProt :

Q460N5 (PAR14_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide	-	PubMed:27796300
	left-to-right	PubMed:27796300

PDB ID: 5NQE