Brand  (β version)

PDB ID: 5NPS

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Ligands
Code Name Style Show Link
94T [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] propyl hydrogen phosphate PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group
NH2 Amino group

Structure summary

Code : 5NPS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The human O-GlcNAc transferase in complex with a bisubstrate inhibitor
Release Data : 2018-05-16
Compound :
mol_id molecule chains synonym
1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit A O-GlcNAc transferase subunit p110,O-linked N-acetylglucosamine transferase 110 kDa subunit,OGT
ec: 2.4.1.255
mol_id molecule chains
2 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: OGT
expression_system_strain: BL21
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Rafie, K., van Aalten, D.
Keywords : O-GlcNAc transferase, GT-B, GT41, Rossman-Fold, active site, inhibitor, transferase
Exp. method : X-RAY DIFFRACTION ( 1.68 Å )
Citation :

Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors.

Rafie, K.,Gorelik, A.,Trapannone, R.  et al.
(2018)  Bioconjug. Chem.  29 : 1834 - 1840

PubMed: 29723473
DOI: 10.1021/acs.bioconjchem.8b00194

Reaction

Chain : A
UniProt : O15294 (OGT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+) 2.4.1.255 PubMed:15361863, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:24563466, PubMed:26237509, PubMed:27713473, PubMed:30699359, PubMed:34074792, PubMed:26369908, PubMed:26678539
left-to-right PubMed:24563466, PubMed:26237509, PubMed:27713473, PubMed:30699359, PubMed:34074792
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+) 2.4.1.255 PubMed:15361863, PubMed:21240259, PubMed:21285374, PubMed:24563466, PubMed:26237509, PubMed:37541260, PubMed:26678539
left-to-right PubMed:24563466, PubMed:26237509, PubMed:27713473, PubMed:37541260
[Isoform 4]
L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+) 		2.4.1.255 PubMed:31527085
left-to-right
[Isoform 4]
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+) 		2.4.1.255 PubMed:31527085
left-to-right