Brand  (β version)

PDB ID: 5NP8

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Ligands
Code Name Style Show Link
3PG 3-phosphoglyceric acid PoSSuM
93T 3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5NP8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : PGK1 in complex with CRT0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid)
Release Data : 2018-05-16
Compound :
mol_id molecule chains synonym
1 Phosphoglycerate kinase 1 A Cell migration-inducing gene 10 protein,Primer recognition protein 2,PRP 2
ec: 2.7.2.3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PGK1, PGKA, MIG10, OK/SW-cl.110
Authors : Turnbull, A.P., Bilsland, A.E., Liu, Y., Sumpton, D., Stevenson, K., Cairney, C.J., Roffey, J., Jenkinson, D., Keith, W.N.
Keywords : Kinase, transferase
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation.

Bilsland, A.E.,Liu, Y.,Turnbull, A.  et al.
(2019)  Neoplasia  21 : 893 - 907

PubMed: 31401411
DOI: 10.1016/j.neo.2019.07.008

Reaction

Chain : A
UniProt : P00558 (PGK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP 2.7.2.3 PubMed:30323285, PubMed:7391028
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:26942675
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:18463139
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