Het-PDB Navi2 (PDB: 5NON)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
93H	4-[2-[2-(4-methoxyphenyl)ethylamino]ethyl]benzene-1,2-diol				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5NON

Code :

5NON PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic

Release Data :

2017-09-27

Compound :

mol_id	molecule	chains
1	S-norcoclaurine synthase	A,B,C
	ec: 4.2.1.78

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Thalictrum flavum subsp. glaucum (taxid:150095)	Yellow meadow rue	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_vector_type: Plasmid expression_system_plasmid: PD451 - SR

Authors :

Sula, A., Lichman, B.R., Pesnot, T., Ward, J.M., Hailes, H.C., Keep, N.H.

Keywords :

Pictet Spengler condensation, Dopamine, lyase

Exp. method :

X-RAY DIFFRACTION ( 1.85 Å )

Citation :

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.

Lichman, B.R.,Sula, A.,Pesnot, T. et al.
(2017) Biochemistry 56 : 5274 - 5277

Chain :

A, B, C

UniProt :

Q67A25 (NCS_THLFG)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O	4.2.1.78	PubMed:15447655, PubMed:17696451, PubMed:19004827
	-	PubMed:15447655, PubMed:17696451, PubMed:19004827

PDB ID: 5NON