Brand  (β version)

PDB ID: 5NOB

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
92T 1-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5NOB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human tankyrase 2 in complex with OD336
Release Data : 2017-11-29
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A,B TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_strain: BL21(DE3)
expression_system_variant: Rosetta 2
Authors : Ignatev, A., Lehtio, L.
Keywords : Transferase
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

Anumala, U.R.,Waaler, J.,Nkizinkiko, Y.  et al.
(2017)  J. Med. Chem.  60 : 10013 - 10025

PubMed: 29155568
DOI: 10.1021/acs.jmedchem.7b00883

Reaction

Chain : A, B
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
-
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
left-to-right