Het-PDB Navi2 (PDB: 5NLK)

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Ligands
Code	Name		Style	Show	Link
92E	~{N}-[3-acetamido-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]phenyl]furan-2-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5NLK

Code :

5NLK PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of CREBBP bromodomain complexd with US13A

Release Data :

2018-02-21

Compound :

mol_id	molecule	chains
1	CREB-binding protein	A
	ec: 2.3.1.48

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: CREBBP, CBP

Authors :

Zhu, J., Caflisch, A.

Keywords :

Inhibitor, Bromodomain, Transferase

Exp. method :

X-RAY DIFFRACTION ( 1.800 Å )

Citation :

Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).

Batiste, L.,Unzue, A.,Dolbois, A. et al.
(2018) ACS Cent Sci 4 : 180 - 188

Chain :

UniProt :

Q92793 (CBP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone]	2.3.1.48	PubMed:24616510
	left-to-right	PubMed:24616510
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]	-	PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
	left-to-right	PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826

PDB ID: 5NLK