Brand  (β version)

PDB ID: 5NKA

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Ligands
Code Name Style Show Link
91H 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5NKA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2g
Release Data : 2017-06-07
Compound :
mol_id molecule chains synonym
1 Ephrin type-A receptor 2 A Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: EPHA2, ECK
Authors : Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
Keywords : Inhibitor, Complex, Protein Tyrosine Kinase, transferase
Exp. method : X-RAY DIFFRACTION ( 1.377 Å )
Citation :

Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.

Heinzlmeir, S.,Lohse, J.,Treiber, T.  et al.
(2017)  ChemMedChem  12 : 999 - 1011

PubMed: 28544567
DOI: 10.1002/cmdc.201700217

Reaction

Chain : A
UniProt : P29317 (EPHA2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:2174105
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