Het-PDB Navi2 (PDB: 5N9P)

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Ligands
Code	Name		Style	Show	Link
CL	Chloride ion				PoSSuM

Non-standard Residues
Code	Name	Show
2L5	2-chloro-L-phenylalanine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
92B	(3~{S},7~{R},10~{R},13~{S})-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid
ACE	Acetyl group
NH2	Amino group

Download interaction data: 5N9P

Code :

5N9P PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING

Title :

ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-NH2

Release Data :

2017-06-14

Compound :

mol_id	molecule	chains	synonym
1	Protein enabled homolog	B,A	ENAH EVH1
	other_details: Only the backbone of S2B was modelled as side chain was not visible

mol_id	molecule	chains
2	Ac-[2-Cl-F]-PP-[ProM-1]-NH2	C,D,E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: ENAH, MENA expression_system_variant: Gold pLysS AG expression_system_vector_type: Plasmid expression_system_plasmid: pGEX-4T-1

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Barone, M., Roske, Y.

Keywords :

proline-rich motif, Ena/VASP inhibitor, actin, protein-protein interaction, Protein binding

Exp. method :

X-RAY DIFFRACTION ( 1.800 Å )

Citation :

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.

Barone, M.,Muller, M.,Chiha, S. et al.
(2020) Proc.Natl.Acad.Sci.USA 117 : 29684 - 29690

PDB ID: 5N9P