Brand  (β version)

PDB ID: 5N87

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Ligands
Code Name Style Show Link
N66 ~{N}-(2,6-diethylphenyl)-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5,6-dihydropyrimido[4,5-E]indolizine-7-carboxamide PoSSuM
NA Sodium ion PoSSuM
PGF 2,5,8,11-tetraoxatridecane PoSSuM
Non-standard Residues
Code Name Show
TPO Phosphothreonine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 5N87   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : TTK kinase domain in complex with NTRC 0066-0
Release Data : 2017-05-31
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase TTK A Phosphotyrosine picked threonine-protein kinase,PYT
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTK, MPS1, MPS1L1
Authors : Uitdehaag, J., Willemsen-Seegers, N., Sterrenburg, J.G., de Man, J., Buijsman, R.C., Zaman, G.J.R.
Keywords : kinase, inhibitor, mitosis, Mps1, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.29 Å )
Citation :

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.

Uitdehaag, J.C.M.,de Man, J.,Willemsen-Seegers, N.  et al.
(2017)  J. Mol. Biol.  429 : 2211 - 2230

PubMed: 28539250
DOI: 10.1016/j.jmb.2017.05.014

Reaction

Chain : A
UniProt : P33981 (TTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:29162720
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 PubMed:29162720
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 PubMed:29162720
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