Het-PDB Navi2 (PDB: 5N7T)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
FAD	Flavin-adenine dinucleotide	PoSSuM
CL	Chloride ion	PoSSuM
JHY	3-(5,6-dichloro-2-oxobenzo[D]oxazol-3(2h)-yl)propanoic acid	PoSSuM
GOL	Glycerol	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5N7T

Code :

5N7T PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Release Data :

2017-06-14

Compound :

mol_id	molecule	chains	synonym
1	Kynurenine 3-monooxygenase	A,B	PfKMO,Kynurenine 3-hydroxylase
	ec: 1.14.13.9 mutation: C252S C461S

Source :

mol_id	organism_scientific	expression_system
1	Pseudomonas fluorescens (taxid:294)	Escherichia coli (taxid:562)
	gene: kmo, qbsG

Authors :

Rowland, P.

Keywords :

KMO, kynurenine 3-monooxygenase, oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 1.81 Å )

Citation :

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

Liddle, J.,Beaufils, B.,Binnie, M. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 2023 - 2028

Chain :

A, B

UniProt :

Q84HF5 (KMO_PSEFL)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)	1.14.13.9	HAMAP-Rule:MF_01971, PubMed:16973376, PubMed:28604669, PubMed:29429898
	-

PDB ID: 5N7T