Het-PDB Navi2 (PDB: 5N58)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
93W	(2~{R})-2-[(1-chloranyl-4-oxidanyl-isoquinolin-3-yl)carbonylamino]-3-(1~{H}-indol-3-yl)propanoic acid	PoSSuM
GOL	Glycerol	PoSSuM

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Download interaction data: 5N58

Code :

5N58 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

di-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1)

Release Data :

2017-05-17

Compound :

mol_id	molecule	chains	synonym
1	Class B metallo-beta-lactamase	A,B	Meta-beta-carbapenem,Metallo-beta-lactamase

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: blaVIM-5 expression_system_variant: PLYSS expression_system_vector_type: plasmid expression_system_plasmid: opinf vector based

Authors :

Li, G.-B., Brem, J., McDonough, M.A., Schofield, C.J.

Keywords :

metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.9570 Å )

Citation :

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.

Li, G.B.,Brem, J.,Lesniak, R. et al.
(2017) Chem. Commun. (Camb.) 53 : 5806 - 5809

PDB ID: 5N58