Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
8NN (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-L-tryptophan
ZN Zinc ion
Modified Residues
Code Name Link
00C 3-sulfo-D-alanine
Code : 5N55
Header : HYDROLASE
Title : mono-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-L-tryptophan (Compound 2)
Release Data : 2017-05-17
Compound :
mol_id molecule chains synonym
1 Class B metallo-beta-lactamase A,B,C Meta-beta-carbapenem,Metallo-beta-lactamase
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli BL21(DE3)  (taxid:469008)
gene: blaVIM-5
expression_system_variant: PLYSS
expression_system_vector_type: plasmid
expression_system_plasmid: opinf vector based
Authors : Li, G.-B., Brem, J., McDonough, M.A., Schofield, C.J.
Keywords : metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.9900 Å )
Citation :

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.

Li, G.B.,Brem, J.,Lesniak, R.  et al.
(2017)  Chem. Commun. (Camb.)  53 : 5806 - 5809

PubMed: 28470248
DOI: 10.1039/c7cc02394d

Chain : A, B, C
UniProt : Q8GKX2 (No found in current UniProtKB/SwissProt)
Reaction : -