Brand  (β version)

PDB ID: 5N3R

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Ligands
Code Name Style Show Link
CDT 4-methylsulfanyl-2-ureido-butyric acid PoSSuM
DMS Dimethyl sulfoxide PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
Non-standard Residues
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SEP Phosphoserine
TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 5N3R   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-(carbamoylamino)-4-methylsulfanylbutanoic acid
Release Data : 2018-02-28
Compound :
mol_id molecule chains synonym
1 cAMP-dependent protein kinase catalytic subunit alpha A PKA C-alpha
ec: 2.7.11.11
Source :
mol_id organism_scientific organism_common expression_system
1 Cricetulus griseus  (taxid:10029) Chinese hamster Escherichia coli BL21(DE3)  (taxid:469008)
gene: PRKACA
expression_system_variant: pLysS
expression_system_vector_type: Plasmid
expression_system_plasmid: pET-16bTEV
Authors : Siefker, C., Heine, A., Klebe, G.
Keywords : fragment, complex, transferase, serine threonine kinase, cAMP, kinase, PKA
Exp. method : X-RAY DIFFRACTION ( 1.36 Å )
Citation :

A crystallographic fragment study with cAMP-dependent protein kinase A

Siefker, C.,Heine, A.,Klebe, G.
To Be Published 

Reaction

Chain : A
UniProt : P25321 (KAPCA_CRIGR)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.11 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.11 -
-