Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
F05 2h-isoindol-1-amine
MPD (4s)-2-methyl-2,4-pentanediol
Modified Residues
Code Name Link
SEP Phosphoserine
TPO Phosphothreonine
Code : 5N36
Title : cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 3H-isoindol-2-ium-1-amine
Release Data : 2018-02-28
Compound :
mol_id molecule chains synonym
1 cAMP-dependent protein kinase catalytic subunit alpha A PKA C-alpha
other_details: Phosphorylation of S11 S140, T198, S339
mol_id molecule chains
2 cAMP dependent protein kinase inhibitor alpha-like protein B
other_details: cAMP dependent protein kinase inhibitor peptide
Source :
mol_id organism_scientific organism_common expression_system
1 Cricetulus griseus  (taxid:10029) Chinese hamster Escherichia coli BL21(DE3)  (taxid:469008)
gene: PRKACA
expression_system_variant: pLysS
expression_system_vector_type: pET-16bTEV
mol_id organism_scientific
2 Cricetulus griseus  (taxid:10029)
synthetic: yes
Authors : Siefker, C., Heine, A., Klebe, G.
Keywords : fragment, complex, transferase, serine threonine kinase, cAMP, kinase, PKA
Exp. method : X-RAY DIFFRACTION ( 1.58 Å )
Citation :

A crystallographic fragment study with cAMP-dependent protein kinase A

Siefker, C.,Heine, A.,Klebe, G.
To Be Published 

Chain : A
UniProt : P25321 (KAPCA_CRIGR)
Reaction : ATP + a protein = ADP + a phosphoprotein.