Brand  (β version)

PDB ID: 5MXR

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
JTY 5-(phenylsulfonylamino)-1,3-thiazole-4-carboxylic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5MXR   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-330 Inhibitor
Release Data : 2018-03-14
Compound :
mol_id molecule chains synonym
1 Beta-lactamase VIM-2 A Class B beta-lactamase,Class B carbapenemase VIM-2,Metallo beta lactamase VIM-2,Metallo beta-lactamase,Metallo-beta-lactamase,Metallo-beta-lactamase VIM-2,Metallo-beta-lactamase vim-2,VIM-2 metallo-beta-lactamase,VIM-2 protein
fragment: VIM-2 mature protein
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:469008)
gene: blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-9a
Authors : Docquier, J.D., De Luca, F., Benvenuti, M., Di Pisa, F., Pozzi, C., Mangani, S.
Keywords : metallo-beta-lactamase fold, zinc-dependent hydrolase, PFam00753, alpha-beta-beta-alpha sandwich, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.7500 Å )
Citation :

SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

Leiris, S.,Coelho, A.,Castandet, J.  et al.
(2019)  Acs Infect Dis.  5 : 131 - 140

PubMed: 30427656
DOI: 10.1021/acsinfecdis.8b00246

Reaction

Chain : A
UniProt : Q9K2N0 (Q9K2N0_PSEAI)
Reaction : -