Brand  (β version)

PDB ID: 5MTX

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Ligands
Code Name Style Show Link
FJI 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-6~{H}-benzo[C][1]benzoxepine-9-carboxamide PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Structure summary

Code : 5MTX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Dibenzooxepinone inhibitor 12b in complex with p38 MAPK
Release Data : 2017-09-06
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Authors : Buehrmann, M., Rauh, D.
Keywords : kinase, inhibitor, p38, complex, type 1.5, transferase
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.

Walter, N.M.,Wentsch, H.K.,Buhrmann, M.  et al.
(2017)  J. Med. Chem.  60 : 8027 - 8054

PubMed: 28834431
DOI: 10.1021/acs.jmedchem.7b00745

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590