Brand  (β version)

PDB ID: 5MRL

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Ligands
Code Name Style Show Link
F2M (~{E})-~{N}-(furan-2-ylmethyl)-~{N}-methyl-prop-1-en-1-amine PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5MRL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)
Release Data : 2017-01-11
Compound :
mol_id molecule chains synonym
1 Amine oxidase [flavin-containing] B A,B Monoamine oxidase type B,MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Komagataella pastoris  (taxid:4922)
gene: MAOB
Authors : Binda, C., De Deurwaerdere, P., Corne, R., Leone, C., Valeri, A., Valoti, M., Ramsay, R.R., Fall, Y., Marco-Contelles, J.
Keywords : monoamine oxidase, neurodegeneration, inhibitor, enzyme, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.42 Å )
Citation :

Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.

De Deurwaerdere, P.,Binda, C.,Corne, R.  et al.
(2017)  ACS Chem Neurosci  8 : 1026 - 1035

PubMed: 27977122
DOI: 10.1021/acschemneuro.6b00377

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine - PubMed:20493079
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an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
left-to-right
dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
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