Brand  (β version)

PDB ID: 5MQG

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Ligands
Code Name Style Show Link
F31 1-(4-azanyl-3-methoxy-phenyl)ethanone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5MQG   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of CREBBP bromodomain complexed with CBP015
Release Data : 2017-04-19
Compound :
mol_id molecule chains
1 CREB-binding protein A,B
ec: 2.3.1.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CREBBP, CBP
Authors : Zhu, J., Spiliotopoulos, D., Caflisch, A.
Keywords : CREBBP bromodomain, Inhibitor, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.350 Å )
Citation :

Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.

Spiliotopoulos, D.,Zhu, J.,Wamhoff, E.C.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 2472 - 2478

PubMed: 28410781
DOI: 10.1016/j.bmcl.2017.04.001

Reaction

Chain : A, B
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone] 2.3.1.48 PubMed:24616510
left-to-right
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826