PDB ID: 5MO8
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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ACT | Acetate ion | PoSSuM | |||
C98 | 3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid | PoSSuM | |||
PO4 | Phosphate ion | PoSSuM |
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Download interaction data: 5MO8
Structure summary
Code : | 5MO8 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound | ||||||||||||
Release Data : | 2017-05-24 | ||||||||||||
Compound : |
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Source : |
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Authors : | Brear, P., De Fusco, C., Georgiou, K., Iegre, J., Sore, H., Hyvonen, M., Spring, D. | ||||||||||||
Keywords : | CK2alpha, CK2a, fragment based drug discovery, high concentration screening, selective ATP competitive inhibitors, surface entrophy reduction, Transferase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.82 Å ) | ||||||||||||
Citation : |
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
De Fusco, C.,Brear, P.,Iegre, J.
et al.
PubMed: 28495381 |
Reaction
Chain : | A, B | ||||||||||||||
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UniProt : | P68400 (CSK21_HUMAN) | ||||||||||||||
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