Brand  (β version)

PDB ID: 5MLJ

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
9ST 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5MLJ   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one
Release Data : 2017-12-20
Compound :
mol_id molecule chains synonym
1 Histone acetyltransferase KAT2A A,B General control of amino acid synthesis protein 5-like 2,Histone acetyltransferase GCN5,HsGCN5,Lysine acetyltransferase 2A,STAF97
ec: 2.3.1.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KAT2A, GCN5, GCN5L2, HGCN5
Authors : Chung, C.-W.
Keywords : INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, GCN5, KAT2A, ANTAGONIST, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

Humphreys, P.G.,Bamborough, P.,Chung, C.W.  et al.
(2017)  J. Med. Chem.  60 : 695 - 709

PubMed: 28002667
DOI: 10.1021/acs.jmedchem.6b01566

Reaction

Chain : A, B
UniProt : Q92830 (KAT2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:16753578, PubMed:17301242, PubMed:23142079, PubMed:27796307, PubMed:29174768, PubMed:35995428
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acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone] 2.3.1.48 PubMed:27377381, PubMed:29211711, PubMed:31527837
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L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl- L-lysyl-[protein] - PubMed:29211711
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glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl- L-lysyl-[protein] - PubMed:31542297
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