Het-PDB Navi2 (PDB: 5ML6)

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Ligands
Code	Name		Style	Show	Link
9GD	2-azanyl-4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl)amino]methyl]benzoic acid				PoSSuM

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Download interaction data: 5ML6

Code :

5ML6 PDBj RCSB PDB PDBe

Header :

LIPID BINDING PROTEIN

Title :

The crystal structure of PDE6D in complex to inhibitor-8

Release Data :

2017-02-01

Compound :

mol_id	molecule	chains	synonym
1	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	B	GMP-PDE delta,Protein p17

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PDE6D, PDED

Authors :

Fansa, E.K., Martin-gago, P., Waldmann, H., Wittinghofer, A.

Keywords :

Prenyl binding protein, farnesylated KRas, Plasma membrane, Arl2, Lipid binding protein

Exp. method :

X-RAY DIFFRACTION ( 1.8700 Å )

Citation :

A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martin-Gago, P.,Fansa, E.K.,Klein, C.H. et al.
(2017) Angew. Chem. Int. Ed. Engl. 56 : 2423 - 2428

PDB ID: 5ML6