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Ligands
Code Name Style Show Link
GOL Glycerol
RNK 4-chloranyl-2-methyl-5-[(3-methylthiophen-2-yl)methylamino]pyridazin-3-one
Non-standard Residues
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Glycosylation
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Modification
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Code : 5MKZ   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one
Release Data : 2017-12-20
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
other_details: SM left over from tag cleavage
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD4, HUNK1
Authors : Chung, C.-W.
Keywords : INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, BRD4, BROMODOMAIN CONTAINING PROTEIN 4, ANTAGONIST, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.62 Å )
Citation :

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

Humphreys, P.G.,Bamborough, P.,Chung, C.W.  et al.
(2017)  J. Med. Chem.  60 : 695 - 709

PubMed: 28002667
DOI: 10.1021/acs.jmedchem.6b01566

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -