Het-PDB Navi2 (PDB: 5MKU)

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Ligands
Code	Name		Style	Show	Link
J57	(~{E})-3-[4-oxidanyl-3-(3-propan-2-ylphenyl)phenyl]prop-2-enoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 5MKU

Code :

5MKU PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 4 and a fragment of the TIF2 co-activator.

Release Data :

2017-11-08

Compound :

mol_id	molecule	chains	synonym
1	Retinoic acid receptor RXR-alpha	A	Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha

mol_id	molecule	chains
2	HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RXRA, NR2B1

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Andrei, S.A., Brunsveld, L., Scheepstra, M., Ottmann, C.

Keywords :

RXR TIF2 honokiol, transcription

Exp. method :

X-RAY DIFFRACTION ( 1.7800 Å )

Citation :

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.

Scheepstra, M.,Andrei, S.A.,de Vries, R.M.J.M. et al.
(2017) ACS Chem Neurosci 8 : 2065 - 2077

PDB ID: 5MKU