Brand  (β version)

PDB ID: 5M8O

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Ligands
Code Name Style Show Link
0TR 2-hydroxycyclohepta-2,4,6-trien-1-one PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
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Structure summary

Code : 5M8O   PDBj   RCSB PDB   PDBe
Header : UNKNOWN FUNCTION
Title : Crystal structure of human tyrosinase related protein 1 in complex with tropolone
Release Data : 2017-07-12
Compound :
mol_id molecule chains synonym
1 5,6-dihydroxyindole-2-carboxylic acid oxidase A,B,C,D DHICA oxidase,Catalase B,Glycoprotein 75,Melanoma antigen gp75,Tyrosinase-related protein 1,TRP1
ec: 1.14.18.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: TYRP1, CAS2, TYRP, TYRRP
expression_system_common: Fall armyworm
Authors : Lai, X., Soler-Lopez, M., Wichers, H.J., Dijkstra, B.W.
Keywords : human tyrosinase related protein 1, melanin biosynthesis, tyrosinase, oxidoreductase, unknown function
Exp. method : X-RAY DIFFRACTION ( 2.5000 Å )
Citation :

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.

Lai, X.,Wichers, H.J.,Soler-Lopez, M.  et al.
(2017)  Angew. Chem. Int. Ed. Engl.  56 : 9812 - 9815

PubMed: 28661582
DOI: 10.1002/anie.201704616

Reaction

Chain : A, B, C, D
UniProt : P17643 (TYRP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole- 5,6-quinone-2-carboxylate - PubMed:28661582
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