Het-PDB Navi2 (PDB: 5M36)

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Ligands
Code	Name	Link
9SZ	(1r,5s,9s,16r,20r,24s,28s,35r)-3,22-bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene	PoSSuM
BEZ	Benzoic acid	PoSSuM
GOL	Glycerol	PoSSuM

Non-standard Residues
Code	Name	Show
CSO	S-hydroxycysteine
SEP	Phosphoserine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 5M36

Code :

5M36 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

The molecular tweezer CLR01 stabilizes a disordered protein-protein interface

Release Data :

2017-11-15

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 protein zeta/delta	A,B	Protein kinase C inhibitor protein 1,KCIP-1

mol_id	molecule	chains	synonym
2	M-phase inducer phosphatase 3	C,D	Dual specificity phosphatase Cdc25C
	ec: 3.1.3.48 mutation: UNP residues 207-244

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: YWHAZ

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Bier, D., Ottmann, C.

Keywords :

Stabilization, 14-3-3, disordered PPI interface, CDC25C, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.4500 Å )

Citation :

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.

Bier, D.,Mittal, S.,Bravo-Rodriguez, K. et al.
(2017) J. Am. Chem. Soc. 139 : 16256 - 16263

Chain :

C, D

UniProt :

P30307 (MPIP3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	-
	-	-

PDB ID: 5M36