Brand  (β version)

PDB ID: 5LOQ

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Ligands
Code Name Style Show Link
FEC 1,3,5,8-tetramethyl-porphine-2,4,6,7-tetrapropionic acid ferrous complex PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
NA Sodium ion PoSSuM
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Structure summary

Code : 5LOQ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of coproheme bound HemQ from Listeria monocytogenes
Release Data : 2016-10-26
Compound :
mol_id molecule chains synonym
1 Putative heme-dependent peroxidase lmo2113 A,B,C,D,E UPF0447 protein lmo2113, HemQ
ec: 1.11.1.-
Source :
mol_id organism_scientific expression_system
1 Listeria monocytogenes  (taxid:1639) Escherichia coli BL21(DE3)  (taxid:469008)
gene: lmo2113
expression_system_vector_type: Plasmid
expression_system_plasmid: pET21(+)
Authors : Puehringer, D., Mlynek, G., Hofbauer, S., Djinovic-Carugo, K., Obinger, C.
Keywords : HemQ, heme biosynthesis, coproheme, heme b, Gram-positive pathogens, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.6900 Å )
Citation :

Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies.

Hofbauer, S.,Mlynek, G.,Milazzo, L.  et al.
(2016)  FEBS J.  283 : 4386 - 4401

PubMed: 27758026
DOI: 10.1111/febs.13930

Reaction

Chain : A, B, C, D, E
UniProt : Q8Y5F1 (CHDC_LISMO)
Reaction: EC: Evidence:
Physiological Direction:
Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b 1.3.98.5 HAMAP- Rule:MF_01442, PubMed:27758026, PubMed:29536725, PubMed:31423350
left-to-right HAMAP-Rule:MF_01442, PubMed:27758026, PubMed:31423350
Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III - HAMAP- Rule:MF_01442, PubMed:31423350
left-to-right HAMAP-Rule:MF_01442, PubMed:27758026, PubMed:31423350
H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b - HAMAP-Rule:MF_01442, PubMed:31423350
left-to-right HAMAP-Rule:MF_01442, PubMed:27758026, PubMed:31423350