Brand  (β version)

PDB ID: 5LKZ

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Ligands
Code Name Style Show Link
COO Crotonyl coenzyme a PoSSuM
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 5LKZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the p300 acetyltransferase catalytic core with crotonyl-coenzyme A.
Release Data : 2016-11-02
Compound :
mol_id molecule chains synonym
1 Histone acetyltransferase p300,Histone acetyltransferase p300 A p300 HAT,E1A-associated protein p300,p300 HAT,E1A-associated protein p300
ec: 2.3.1.48,2.3.1.48
fragment: UNP residues 1043-1519,UNP residues 1581-1666,UNP residues 1043-1519,UNP residues 1581-1666
mutation: Y1467F,Y1467F,Y1467F,Y1467F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: EP300, P300
expression_system_common: Cabbage looper
expression_system_cell_line: High Five
Authors : Kaczmarska, Z., Ortega, E., Marquez, J.A., Panne, D.
Keywords : p300 acetyltransferase, crotonyl-CoA, chromatin modification, acylation, transferase
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Structure of p300 in complex with acyl-CoA variants.

Kaczmarska, Z.,Ortega, E.,Goudarzi, A.  et al.
(2017)  Nat. Chem. Biol.  13 : 21 - 29

PubMed: 27820805
DOI: 10.1038/nchembio.2217

Reaction

Chain : A
UniProt : Q09472 (EP300_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 PubMed:15448695, PubMed:17761950, PubMed:23415232, PubMed:23934153, PubMed:24120661, PubMed:30197302, PubMed:32561715, PubMed:8945521
left-to-right PubMed:15448695, PubMed:30197302, PubMed:32561715
(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- (2E)-butenoyl-L-lysyl-[protein] - PubMed:25818647
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butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl- L-lysyl-[protein] - UniProtKB:B2RWS6
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L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)- propanoyl-L-lysyl-[protein] - PubMed:17267393
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2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] - PubMed:29775581
left-to-right
L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L- lysyl-[protein] - PubMed:31645732
left-to-right