PDB ID: 5L8Y
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Structure summary
Code : | 5L8Y PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-937 | ||||||||||||
Release Data : | 2018-03-14 | ||||||||||||
Compound : |
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Source : |
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Authors : | Singh, A.K., Anthonyrajah, E.S., Brown, D.G. | ||||||||||||
Keywords : | parasitic PDE, African Trypanosomiasis, sleeping sickness, hydrolase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.14 Å ) | ||||||||||||
Citation : |
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
Blaazer, A.R.,Singh, A.K.,de Heuvel, E.
et al.
PubMed: 29672041 |
Reaction
Chain : | A, B |
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UniProt : | Q8WQX9 (Q8WQX9_9TRYP) |
Reaction : | - |