Het-PDB Navi2 (PDB: 5KHG)

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Ligands
Code	Name		Style	Show	Link
CC7	4-amino-1-[(2s,4ar,6r,7r,7as)-2,7-dihydroxy-2-oxidotetrahydro-4h-furo[3,2-D][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1h)-one				PoSSuM

Non-standard Residues
Code	Name	Show
CSX	S-oxy cysteine

Glycosylation
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Download interaction data: 5KHG

Code :

5KHG PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)

Release Data :

2016-09-14

Compound :

mol_id	molecule	chains	synonym
1	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	A	Brain cyclic nucleotide-gated channel 2,BCNG-2,Hyperpolarization-activated cation channel 1,HAC-1
	fragment: UNP residues 443-643

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:469008)
	gene: Hcn2, Bcng2, Hac1 expression_system_strain: BL21(DE3) expression_system_vector_type: plasimd expression_system_plasmid: pET28

Authors :

Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A.

Keywords :

protein-ligand complex, cycilc nucleotide binding domain, ion transport, TRANSPORT PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.2410 Å )

Citation :

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.

Ng, L.C.,Putrenko, I.,Baronas, V. et al.
(2016) Structure 24 : 1629 - 1642

Chain :

UniProt :

O88703 (HCN2_MOUSE)

PDB ID: 5KHG