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Ligands
Code Name Style Show Link
ACT Acetate ion
CE9 Dodecyl nona ethylene glycol ether
CL Chloride ion
FNR 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[G]pteridin-1-id-10(5h)-yl)-5-O-phosphonato-D-ribitol
GOL Glycerol
ORO Orotic acid
SO4 Sulfate ion
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Code : 5K9D   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution
Release Data : 2016-10-12
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
fragment: residues 29-395
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
expression_system_strain: Rosetta(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Lewis, T.A., Sykes, D.B., Law, J.M., Munoz, B., Scadden, D.T., Rustiguel, J.K., Nonato, M.C., Schreiber, S.L.
Keywords : oxidoreductase, alpha/beta barrel
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.

Lewis, T.A.,Sykes, D.B.,Law, J.M.  et al.
(2016)  ACS Med Chem Lett  7 : 1112 - 1117

PubMed: 27994748
DOI: 10.1021/acsmedchemlett.6b00316

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
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