Brand  (β version)

PDB ID: 5JZS

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Ligands
Code Name Style Show Link
FGZ 3,5-dichloro-4-hydroxybenzoic acid PoSSuM
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Structure summary

Code : 5JZS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid
Release Data : 2017-04-05
Compound :
mol_id molecule chains synonym
1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD A,B HsaD
ec: 3.7.1.8
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Pseudomonas putida  (taxid:303)
gene: bphD, AFL40_3716, BN1213_03918, BN1303_03049, ERS007661_00365, ERS007663_01172, ERS007665_00879, ERS007670_01859, ERS007679_00575, ERS007722_01141, ERS007741_03068, ERS013471_01596, ERS024213_01658, ERS027646_02381, ERS027654_01339, ERS027656_01041, ERS027661_00436, ERS124361_01169
expression_system_strain: KT2442
expression_system_vector_type: Plasmid
expression_system_plasmid: PVLT31
Authors : Ryan, A., Polycarpou, E., Lack, N., Evangelopoulos, D., Sieg, C., Halman, A., Bhakta, S., Sinclair, A., Eleftheriadou, O., McHugh, T.D., Keany, S., Lowe, E.D., Ballet, R., Abuhammad, A., Ciulli, A., Sim, E.
Keywords : HsaD, inhibitor, M. tuberculosis, cholesterol, infection, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.2700 Å )
Citation :

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan, A.,Polycarpou, E.,Lack, N.A.  et al.
(2017)  Br. J. Pharmacol.  174 : 2209 - 2224

PubMed: 28380256
DOI: 10.1111/bph.13810

Reaction

Chain : A, B
UniProt : A0A045KDP6 (A0A045KDP6_MYCTX)
Reaction : -