Het-PDB Navi2 (PDB: 5JZS)

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Ligands
Code	Name		Style	Show	Link
FGZ	3,5-dichloro-4-hydroxybenzoic acid				PoSSuM

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Glycosylation
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Download interaction data: 5JZS

Code :

5JZS PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid

Release Data :

2017-04-05

Compound :

mol_id	molecule	chains	synonym
1	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD	A,B	HsaD
	ec: 3.7.1.8

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis (taxid:1773)	Pseudomonas putida (taxid:303)
	gene: bphD, AFL40_3716, BN1213_03918, BN1303_03049, ERS007661_00365, ERS007663_01172, ERS007665_00879, ERS007670_01859, ERS007679_00575, ERS007722_01141, ERS007741_03068, ERS013471_01596, ERS024213_01658, ERS027646_02381, ERS027654_01339, ERS027656_01041, ERS027661_00436, ERS124361_01169 expression_system_strain: KT2442 expression_system_vector_type: Plasmid expression_system_plasmid: PVLT31

Authors :

Ryan, A., Polycarpou, E., Lack, N., Evangelopoulos, D., Sieg, C., Halman, A., Bhakta, S., Sinclair, A., Eleftheriadou, O., McHugh, T.D., Keany, S., Lowe, E.D., Ballet, R., Abuhammad, A., Ciulli, A., Sim, E.

Keywords :

HsaD, inhibitor, M. tuberculosis, cholesterol, infection, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.2700 Å )

Citation :

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan, A.,Polycarpou, E.,Lack, N.A. et al.
(2017) Br. J. Pharmacol. 174 : 2209 - 2224

PubMed: 28380256
DOI: 10.1111/bph.13810

PDB ID: 5JZS

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