Brand  (β version)

PDB ID: 5JZE

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Ligands
Code Name Style Show Link
AYE Prop-2-en-1-amine PoSSuM
FLC Citrate anion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5JZE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Erve virus viral OTU domain protease in complex with mouse ISG15
Release Data : 2016-10-19
Compound :
mol_id molecule chains synonym
1 Ubiquitin-like protein ISG15 B,D Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein
fragment: C-terminal
mol_id molecule chains
2 RNA-dependent RNA polymerase A,C
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:469008)
gene: Isg15, G1p2, Ucrp
expression_system_strain: BL21(DE3)
mol_id organism_scientific expression_system
2 Erve virus  (taxid:248062) Escherichia coli  (taxid:469008)
gene: RdRP
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET11a
Authors : Deaton, M.K., Dzimianski, J.V., Pegan, S.D.
Keywords : vOTU, ISG15, nairovirus, protease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.4700 Å )
Citation :

Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species.

Deaton, M.K.,Dzimianski, J.V.,Daczkowski, C.M.  et al.
(2016)  J.Virol.  90 : 8314 - 8327

PubMed: 27412597
DOI: 10.1128/JVI.00975-16

Reaction

Chain : B, D
UniProt : Q64339 (ISG15_MOUSE)
Reaction : -
Chain : A, C
UniProt : J3RTH4 (J3RTH4_9VIRU)
Reaction : -