PDB ID: 5JRQ
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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6N9 | N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-B]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide | PoSSuM | |||
DMS | Dimethyl sulfoxide | PoSSuM | |||
GOL | Glycerol | PoSSuM | |||
TMA | Tetramethylammonium ion | PoSSuM |
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Download interaction data: 5JRQ
Structure summary
Code : | 5JRQ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE inhibitor | ||||||||||||
Title : | BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM | ||||||||||||
Release Data : | 2016-09-14 | ||||||||||||
Compound : |
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Authors : | Grasso, M.J., Marmorstein, R. | ||||||||||||
Keywords : | kinase, dimer, TRANSFERASE-TRANSFERASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.2870 Å ) | ||||||||||||
Citation : |
Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Grasso, M.,Estrada, M.A.,Ventocilla, C.
et al.
PubMed: 27571413 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | P15056 (BRAF_HUMAN) | ||||||||||||
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