Het-PDB Navi2 (PDB: 5JQS)

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Ligands
Code	Name	Link
AYE	Prop-2-en-1-amine	PoSSuM
CL	Chloride ion	PoSSuM
DIO	1,4-diethylene dioxide	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5JQS

Code :

5JQS PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin

Release Data :

2016-06-22

Compound :

mol_id	molecule	chains
1	Protein FAM63A	A

mol_id	molecule	chains	synonym
2	Ubiquitin-40S ribosomal protein S27a	D	Ubiquitin carboxyl extension protein 80

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FAM63A, KIAA1390 expression_system_vector_type: plasmid expression_system_plasmid: pGEX6P1

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Bovine	Bos taurus (taxid:9913)
	cell: Erythrocytes gene: RPS27A, UBA80, UBCEP1

Authors :

Abdul Rehman, S.A., Kulathu, Y.

Keywords :

Hydrolase, Cysteine protease, isopeptidase and Ubiquitin binding

Exp. method :

X-RAY DIFFRACTION ( 2.650 Å )

Citation :

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.

Abdul Rehman, S.A.,Kristariyanto, Y.A.,Choi, S.Y. et al.
(2016) Mol.Cell 63 : 146 - 155

Chain :

UniProt :

Q8N5J2 (MINY1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).	3.4.19.12	PubMed:27292798
	-	PubMed:27292798

PDB ID: 5JQS