Brand  (β version)

PDB ID: 5JQ8

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Ligands
Code Name Style Show Link
I73 (3s,4s)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5JQ8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of CDK2 in complex with inhibitor ICEC0943
Release Data : 2017-02-08
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CDK2, CDKN2
expression_system_vector_type: Plasmid
expression_system_vector: pProEx
Authors : Hazel, P., Freemont, P.S.
Keywords : Kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.

Hazel, P.,Kroll, S.H.,Bondke, A.  et al.
(2017)  ChemMedChem  12 : 372 - 380

PubMed: 28125165
DOI: 10.1002/cmdc.201600535

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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