Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
03S Methanesulfonic acid
6K9 (1s,3s,6s,9s,12s,14r,16r,18s,20r,21r,22s,26r,29s,31r,32s,33r,35r,36s)-20-[(2s)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name)
ACP Phosphomethylphosphonic acid adenylate ester
CA Calcium ion
GDP Guanosine-5'-diphosphate
GOL Glycerol
GTP Guanosine-5'-triphosphate
IMD Imidazole
MES 2-(N-morpholino)-ethanesulfonic acid
MG Magnesium ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 5JH7   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Tubulin-Eribulin complex
Release Data : 2016-06-29
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mol_id molecule chains
4 Tubulin Tyrosine Ligase F
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Doodhi, H., Prota, A.E., Rodriguez-Garcia, R., Xiao, H., Custar, D.W., Bargsten, K., Katrukha, E.A., Hilbert, M., Hua, S., Jiang, K., Grigoriev, I., Yang, C.-P.H., Cox, D., Band Horwitz, S., Kapitein, L.C., Akhmanova, A., Steinmetz, M.O.
Keywords : CELL CYCLE, CYTOSKELETON, TUBULIN FOLD, MICROTUBULE
Exp. method : X-RAY DIFFRACTION ( 2.250 Å )
Citation :

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.

Doodhi, H.,Prota, A.E.,Rodriguez-Garcia, R.  et al.
(2016)  Curr.Biol.  26 : 1713 - 1721

PubMed: 27321995
DOI: 10.1016/j.cub.2016.04.053

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - UniProtKB:P68363
left-to-right
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -