Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CA Calcium ion
0GJ L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide
DMS Dimethyl sulfoxide
Code : 5JBB
Header : HYDROLASE
Title : Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone
Release Data : 2016-06-01
Compound :
mol_id molecule chains synonym
1 Coagulation factor IX E Christmas factor,Plasma thromboplastin component,PTC
ec: 3.4.21.22
other_details: Fragment: EGF2 DOMAIN, RESIDUES 133-191
mol_id molecule chains synonym
2 Coagulation factor IX S Christmas factor,Plasma thromboplastin component,PTC
ec: 3.4.21.22
mutation: V16I K98T Y177T I213V
other_details: Fragment: CATALYTIC DOMAIN, RESIDUES 227-461
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: F9
expression_system_variant: NiCo21
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: F9
expression_system_variant: NiCo21
Authors : Kristensen, L.H., Brandstetter, H.
Keywords : BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS
Exp. method : X-RAY DIFFRACTION ( 1.5600 Å )
Citation :

Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.

Kristensen, L.H.,Olsen, O.H.,Blouse, G.E.  et al.
(2016)  Biochem.J.  473 : 2395 - 2411

PubMed: 27208168
DOI: 10.1042/BCJ20160336

Chain : S
UniProt : P00740 (FA9_HUMAN)
Reaction : Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.