Het-PDB Navi2 (PDB: 5JB8)

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Ligands
Code	Name	Link
0GJ	L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide	PoSSuM
CA	Calcium ion	PoSSuM
DMS	Dimethyl sulfoxide	PoSSuM

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Download interaction data: 5JB8

Code :

5JB8 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of factor IXa variant K98T in complex with EGR-chloromethylketone

Release Data :

2016-06-01

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor IX	E	Christmas factor,Plasma thromboplastin component,PTC
	ec: 3.4.21.22 other_details: Fragment: EGF2 DOMAIN, RESIDUES 133-191

mol_id	molecule	chains	synonym
2	Coagulation factor IX	S	Christmas factor,Plasma thromboplastin component,PTC
	ec: 3.4.21.22 mutation: K98T other_details: Fragment: CATALYTIC DOMAIN, RESIDUES 227-461

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: F9 expression_system_variant: NiCo21

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: F9 expression_system_variant: Nico21

Authors :

Kristensen, L.H., Brandstetter, H.

Keywords :

BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS

Exp. method :

X-RAY DIFFRACTION ( 1.4500 Å )

Citation :

Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.

Kristensen, L.H.,Olsen, O.H.,Blouse, G.E. et al.
(2016) Biochem.J. 473 : 2395 - 2411

Chain :

UniProt :

P00740 (FA9_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.22	PubMed:12444082, PubMed:20121197, PubMed:20121198, PubMed:2592373
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PDB ID: 5JB8