Het-PDB Navi2 (PDB: 5IGW)

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Ligands
Code	Name	Link
CTY	Clarithromycin	PoSSuM
GDP	Guanosine-5'-diphosphate	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Download interaction data: 5IGW

Code :

5IGW PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Macrolide 2'-phosphotransferase type II - complex with GDP and clarithromycin

Release Data :

2017-04-26

Compound :

mol_id	molecule	chains	synonym
1	Macrolide 2'-phosphotransferase II	A	Macrolide 2'-phosphotransferase II protein MphB,Macrolide 2-phosphotransferase,mph(B)

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:469008)
	gene: mphB, pO103_99 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Berghuis, A.M., Fong, D.H.

Keywords :

macrolide phosphotransferase, kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.096 Å )

Citation :

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Fong, D.H.,Burk, D.L.,Blanchet, J. et al.
(2017) Structure 25 : 750 - 761.e5

PDB ID: 5IGW