Brand  (β version)

PDB ID: 5I9L

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Ligands
Code Name Style Show Link
9W7 2-(2-chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol PoSSuM
GOL Glycerol PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 5I9L   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of B. pseudomallei FabI in complex with NAD and PT404
Release Data : 2017-02-22
Compound :
mol_id molecule chains
1 Enoyl-[acyl-carrier-protein] reductase [NADH] A
ec: 1.3.1.9
Source :
mol_id organism_scientific expression_system
1 Burkholderia pseudomallei  (taxid:28450) Escherichia coli  (taxid:562)
gene: fabI, fabI_2, ACT79_25590, AM256_11615, AM257_11635, AMS56_08605, DP46_2957, DP49_6839, ERS012314_03793, ERS012372_03823, SY87_14645, TR70_1075, VU09_13745
Authors : Hirschbeck, M.W., Eltschkner, S., Tonge, P.J., Kisker, C.
Keywords : enoyl-ACP reductase, Burkholderia pseudomallei, diphenyl ethers, slow-binding inhibitors, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles, C.,Eltschkner, S.,Cummings, J.E.  et al.
(2017)  Biochemistry  56 : 1865 - 1878

PubMed: 28225601
DOI: 10.1021/acs.biochem.6b01048

Reaction

Chain : A
UniProt : A0A069B9A4 (A0A069B9A4_BURPE)
Reaction: EC: Evidence:
Physiological Direction:
a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH 1.3.1.9 PIRNR:PIRNR000094
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