Brand  (β version)

PDB ID: 5I0K

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Ligands
Code Name Style Show Link
COO Crotonyl coenzyme a PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 5I0K   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
Release Data : 2017-08-09
Compound :
mol_id molecule chains synonym
1 Phthiocerol synthesis polyketide synthase type I PpsC A Beta-ketoacyl-acyl-carrier-protein synthase I
ec: 2.3.1.41
fragment: UNP residues 921-1224
mutation: H959F
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli BL21(DE3)  (taxid:469008)
gene: ppsC, Rv2933
expression_system_vector_type: Plasmid
expression_system_vector: pET28a
Authors : Faille, A., Mourey, L., Pedelacq, J.D.
Keywords : dehydratase, polyketide, complex, tuberculosis, transferase
Exp. method : X-RAY DIFFRACTION ( 3.197 Å )
Citation :

Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.

Faille, A.,Gavalda, S.,Slama, N.  et al.
(2017)  J. Mol. Biol.  429 : 1554 - 1569

PubMed: 28377293
DOI: 10.1016/j.jmb.2017.03.026

Reaction

Chain : A
UniProt : P96202 (PPSC_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)- methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C32- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O 2.3.1.292 PubMed:15749014, PubMed:20553505
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docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)- methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C34- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O 2.3.1.292 PubMed:15749014, PubMed:20553505
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17-(4-hydroxyphenyl)heptadecanoyl- [(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C35- (phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O 2.3.1.292 PubMed:15749014, PubMed:20553505
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19-(4-hydroxyphenyl)nonadecanoyl- [(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C37- (phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O 2.3.1.292 PubMed:15749014, PubMed:20553505
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Cofactor: Evidence: Note:
NADP(+) ECO:0000269 | PubMed:15749014
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pantetheine 4'-phosphate ECO:0000269 | PubMed:28203522
Binds 1 phosphopantetheine covalently.