Het-PDB Navi2 (PDB: 5HRQ)

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Color scheme of protein:

Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
IPH	Phenol	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
Code	Name	Show
HZP	(4s)-4-hydroxy-L-proline

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5HRQ

Code :

5HRQ PDBj RCSB PDB PDBe

Header :

HORMONE

Title :

Insulin with proline analog HzP at position B28 in the R6 state

Release Data :

2017-01-25

Compound :

mol_id	molecule	chains
1	Insulin A-Chain	A,C,E,G,I,K

mol_id	molecule	chains
2	Insulin B-Chain	B,D,F,H,J,L
	mutation: Pro28Hzp

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: INS expression_system_strain: CAG18515 expression_system_plasmid: pQE80L

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: INS expression_system_strain: CAG18515 expression_system_plasmid: pQE80L

Authors :

Lieblich, S.A., Fang, K.Y., Cahn, J.K.B., Tirrell, D.A.

Keywords :

Insulin, non-canonical amino acid, hydroxyproline, non-natural amino acid, unnatural amino acid, HORMONE

Exp. method :

X-RAY DIFFRACTION ( 1.28 Å )

Citation :

4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.

Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B. et al.
(2017) J. Am. Chem. Soc. 139 : 8384 - 8387

PDB ID: 5HRQ