Brand  (β version)

PDB ID: 5HQ3

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
VX O-ethylmethylphosphonic acid ester group PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM

Structure summary

Code : 5HQ3
Header : HYDROLASE
Title : Stable, high-expression variant of human acetylcholinesterase
Release Data : 2016-07-27
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A AChE
ec: 3.1.1.7
mol_id molecule chains synonym
2 Acetylcholinesterase B AChE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ACHE
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ACHE
Authors : Goldenzweig, A., Goldsmith, M., Hill, S.E., Gertman, O., Laurino, P., Ashani, Y., Dym, O., Albeck, S., Unger, T., Prilusky, J., Lieberman, R.L., Aharoni, A., Silman, I., Sussman, J.L., Tawfik, D.S., Fleishman, S.J.
Keywords : Design, De Novo Protein, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

Goldenzweig, A.,Goldsmith, M.,Hill, S.E.  et al.
(2016)  Mol.Cell  63 : 337 - 346

PubMed: 27425410
DOI: 10.1016/j.molcel.2016.06.012

Reaction

Chain : B
UniProt : P22303 (ACES_HUMAN)
Reaction : Acetylcholine + H(2)O = choline + acetate.